G2-M Phase of the Cell Cycle
| PAG Title | G2-M Phase of the Cell Cycle |
| PAG ID | WIG001817 |
| Type | P |
| Source Link |  Spike |
| Publication Reference | NA |
| PAG Description | The entry of a cell into mitosis is regulated by an elaborate network of kinases and phosphatases, that controls both the timing of the division, and the complete reorganization of the cellular architecture. Cyclin/Cdk1(CDC2) is thought to be the major kinase that initiates the onset of mitosis. The checkpoint kinases CHEK1 and CHEK2, when activated by ATM, mediated the CycB-CDC2 complex activity by inhibiting its direct activator CDC25C. The transcription factor FoxM1, peaking in the late G2 phase, directly enhance cyclin B transcription. Transcription factors and protein modifiers regulates the amount of the components of the large multiprotein complexes involved in the mitosis progression (cohesin, centromer-kynetochore and the mitotic spindle), their recruitment and the activity of these complexes. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 3,974 |
| Information Content | Rich |
| Other IDs | SPIKE00002 |
| Base PAG ID | WIG001817 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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